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( 1) of total serum T3 ( TT3 ) determination ( normal): 1.23 ~3.39 nmo1/L increased in pregnancy, hyperthyroidism, acute hepatitis; reduce in hypothyroidism, chronic malnutrition, fasting or the risk of certain systemic diseases. Analysis of TT3 should pay attention to:①the serum levels of TT3 is less than TT4, but the physiological role of T3 more than T4 times, the T4 must be converted to T3 function, the T3 on hyperthyroidism diagnostic sensitivity is superior to T4. ( 2) of total serum T4 ( TT4 ) determination ( normal): 71.5 ~115.7 nmol/L increase in: hyperthyroidism, pregnancy, and the use of estrogen, contraceptives, dextro thyroxine, thyroid extract and thyroid-stimulating hormone ( TSH ); reduction in: hypothyroidism, low protein bacteraemia, and make use of phenytoin, thyroxine, three ACTH, Cortison.
Analysis of TT4 should pay attention to:①the method for the patient without radiation hazard, suitable for lactating women and children; the determination of T4 and TSH is the diagnosis of neonatal congenital hypothyroidism only method, better than PBI, 131I, but also by binding protein;③hypothyroidism decreased TT4 than T3 significantly, but to light hyperthyroidism and thyrotoxicosis are early than T3 sensitive, so T3, T4 combined simultaneous determination.
( 3) the determination of serum rT3 ( rT3 3, 3`, 5`- three iodine thyroid raw ammonia acid, also known as the T3 ) ( normal) 0.2~ 0.8 nmo1/L is mainly used for the estimation of thyroid function, thyroid hormone metabolism and Discussion on Mechanism of drug treatment. Diagnosis of hyperthyroidism with T3, T4 sensitive, diagnosis of hypothyroidism is also superior to T3, T4, TSH; in the use of thyroid hormone therapy, if rT3, T3 normal dosage used properly, said: if rT3, T3 increased significantly, while T4 normal or high dosage, prompts the use of too large. ( 4) the serum levels of FT3 and FT4 determination ( free T3, free T4 ( FT3 ): normal values ) from 6 to 11.4 Pmo1/L FT4 6.5 Pmol/L 32.5 soil which is at present the best of thyroid function tests, can more accurately reflect the thyroid function.
Hyperthyroidism FT3, FT4 were higher than TT3, TT4, sensitive, hypothyroidism decreased FT4. It is not widely used in clinical. ( 5) thyroid-stimulating hormone ( TSH ) reaction test: ( normal ) second suction 131 iodine rate compared with control values increased 1 times, 3.4 ±4 mU/L is mainly used for the identification of hypothyroidism properties, primary TSH has no reaction, secondary and normal human TSH reflect the clear, second suction 131 iodine rate control value increased 1 times above, can understand after thyroid ablation of residual thyroid function reserve, if not responding to TSH, prompting the remaining thyroid function have peaked, a reaction that thyroid are potential. Heart failure can make this test.
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