甲状腺毒性周期性麻痹症

    The periodic paralysis is a many causes and symptoms similar to those of syndrome, the symptoms include: 1 systemic or localized muscle weakness in 2 episodes of muscle weakness can be maintained for several days time from 3 muscle weakness by proximal limb spread to remote 4 respiration and cranial nerves are generally not violated 5 at rest after exercise a can produce muscle weakness, continue to mild exercise, symptoms will杭州解放军医院甲亢科 improve in 6 episodes of deep tendon reflexes to reduce or disappear. In the western countries often find there are familial, and Eastern countries but with associated with thyroid abnormalities were mostly, thyrotoxic periodic paralysis with hyperthyroidism, hypokalemia and sudden muscle weakness syndrome. This paper introduces the thyrotoxic periodic paralysis history, epidemiology, genetics, clinical presentation, and the relationship between the thyroid gland, and the method of treatment, for reference. History 1727, the first periodic paralysis case, was suspected of hysteria. In 1882, a 44 year old male was identified with periodic paralysis in 25 years, the patient 's father at the age of 54 from periodic paralysis. In 1902, scholars have described first periodic paralysis associated with hyperthyroidism relationship. In 1931, thyrotoxic periodic paralysis case published in english. After a report of a case with Japanese and Chinese majority. Epidemiology of thyrotoxic periodic paralysis occurred age 20 to 40 years old between, in Japanese men and women suffering from the disease in the United States is the ratio of 20:1, 48:1, 76:1 in Chinese is. Hyperthyroidism Japanese, thyrotoxic periodic paralysis occurred in 1.8%, Chinese 1.9%, Americans are 0.1% to 0.2%, about 1/10 for Asians, Americans were 1/3 Asian, so the thyrotoxic periodic paralysis occurs mainly in the Asian population. Genetic studies have found, thyrotoxic periodic paralysis patients with human leukocyte antigen A2, Bw22, Aw19 and B17, on Hongkong Chinese study out of human leukocyte antigen Bw46 and thyrotoxic periodic paralysis are correlated, and Japanese studies, thyroid gland toxicity of periodic paralysis P common human white blood cell antigen A2, Cw3 and DRw8. The thyrotoxic periodic paralysis and human leukocyte antigen relationship, there is no conclusion. Clinical manifestations of thyrotoxic periodic paralysis associated with familial periodic paralysis clinical symptoms and biochemical manifestations,

         the patient experienced recurrent lower extremity soft and weak, upper limb may also be affected, but less severe, muscle weakness of proximal than most remote severe, acute attack, from mild limb weakness to complete weakness, or respiratory muscle weakness, but do not invade cranial nerves, a small number of patients have premonitory symptoms, such as muscle acid, tight, cramps and other. Sensory function of normal, consciousness is not affected, deep tendon reflexes to reduce or disappear. TPP thyroid toxicity symptoms are usually mild, 杭州江干区人民医院甲亢有看吗 even not obviously. Thyrotoxic periodic paralysis is the most important biochemical changes reduce blood potassium. Reduce blood potassium and potassium ion storage is not enough, but moved to the intracellular potassium ion induced by serum potassium value, the lower the degree of more severe myasthenia gravis, from 3 to 36 hours of recovery, potassium ions can be accelerated recovery. Some factors can induce thyrotoxic periodic paralysis episodes, mainly for the ingestion of carbohydrate and after strenuous exercise, rest, interestingly hypotonia occurred, mild exercise, can reduce the gravis, accelerated recovery. Other predisposing factors of injury, exposure to cold environment, infection, menses, emotion, drinking and so on, but the majority of thyrotoxic periodic paralysis patient without predisposing factors. Summer is often episodes of season, common in May to October,杭州看甲减的医院哪个好点 probably due to sweat loss of potassium ions and drinking high sugar beverages. The most common attack time at night, 88.5% occurred on the night of six to eight in the morning. Thyrotoxic periodic paralysis and the relationship between thyroid familial periodic paralysis patients with normal thyroid function, thyroid hormone administration does not aggravate symptoms, thyrotoxic periodic paralysis patients only in the hyperthyroidism gravis occurs, if the normal thyroid function, ingestion of carbohydrate does not cause gravis attack. 80% thyrotoxic periodic paralysis in patients with hyperthyroidism symptoms than the myasthenic symptoms as early as three months to nine years, 20% both symptoms occur simultaneously. The treatment mainly to restore normal thyroid function principle, as long as the thyroid function returned to normal, myasthenia gravis can stop seizures.

      In the treatment of thyroid function returned to normal during the period, patients should avoid excessive exercise, ingestion of carbohydrate and alcohol, daily oral potassium chloride for the prevention of seizures. If once the hypokalemia occurs, intravenous potassium ions can be accelerated recovery. Conclusion in Asia, hypokalemic periodic paralysis is a common complication of hyperthyroidism. Thyrotoxic periodic paralysis occurs in males, less family history. Clinical thyroid toxicity symptoms may not be apparent, for hypokalemia patients, thyroid function tests are necessary. Thyrotoxic periodic paralysis treated in Department of internal medicine, or surgical approach to thyroid function returned to normal to.杭州看甲减什么医院好 Myasthenia gravis in acute onset, supplement of potassium, contractible short time, usually oral potassium ion can be prevented with thyrotoxic periodic paralysis myasthenia gravis attack.