甲亢突眼病原因

    Suffering from hyperthyroidism exophthalmos甲状腺 usually occurs in patients with proptosis, eyelid retraction, eyelid closure bad or no closure and other symptoms, according to the Hangzhou Tongji Hospital to experts, the disease causes related to the following factors:

    Disease cause of hyperthyroid exophthalmos:

    [ 1 ] the ball after the关于治疗甲状腺病的医院 role of fibroblast immunohistochemistry staining showed extraocular muscle, fat cells, infiltration of inflammatory cells in the presence of IGF-I. While IGF-I and fibroblast growth factor ( FGF ) has stimulated fibroblasts author. Therefore the morbidity associated with this exophthalmos.

    [ 2 ] environmental factors size observed in hyperthyroid patients, found with exophthalmos in 83% smokers, and no exophthalmos 40% only smoking, smoking tips may be involved in the occurrence of exophthalmos.

    [ 3 ] the humoral immunity generally, exophthalmos is autoimmune disease. Eye and thyroid, presence of antigenic determinants of TSH receptors, antigens, thyroglobulin anti thyroglobulin 国内甲亢治疗最佳医院 antibodies and immune complexes, bacteria, viruses and other foreign antigen antibody may also play a role in the pathogenesis.

    [ 4 ] Study on cellular immunity of patients with exophthalmos extraocular muscle T cell is found, the T cell recognition of extraocular muscle antigens and the ability, can stimulate T cell proliferation and migration inhibitory factor, many patients have antibodies, dependent cell mediated cytotoxicity ( ADCC ), NK activity in patients with low half of exophthalmos autoantibodies generated, so a hyperfunctional state.

    [ 5 ] autoimmune cells cultured in vitro in animal models, the data shows the ocular tissue memory have organ-specific antigens, belong to independent organ specific autoimmune disease. Endocrine infiltrative exophthalmos patients blood had detectable extraocular muscle 64KDa protein and its specificity antibody, presumably, exophthalmos may occur and this protein has the relations.

    [ 6 ] genetic determinants of human cell 广州治甲状腺医院 compatibility antigen ( HLA ) and exophthalmos are closely related, with exophthalmos hyperthyroid patients sites of HLABgDR3 positive was significantly more than no exophthalmos hyperthyroid patients.